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各研究分野における代表的な研究成果です。
個々のスタッフの研究業績等については、スタッフ紹介より御覧下さい。

【環境医学・産業医学研究分野 / Environmental Medicine and Occupational Medicine】

  1. Nakano M, Shinagawa T, Eitaki Y, Omae K, Takeuchi A, Iwasawa S, Fukai K, Yoshioka N, Tanaka S, Koda S, Sobue T, Takebayashi T. Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines. Int Arch Occup Environ Health. 2021 Mar 2. doi: 10.1007/s00420-021-01658-2. Epub ahead of print.  PMID: 33651159.
  2. Nakano M, Hirata M, Hamasaki M, Tanaka A, Nagata A, Kumazoe H, Wakamatsu K, Shiraishi T, Omae K. Indium kinetics in an indium exposed worker before and after bilateral lung transplantation. J Occup Health. 2020;62(1):e12165. doi: 10.1002/1348-9585.12165.  PMID: 32951288; PMCID: PMC7507028.
  3. Nakano M, Omae K, Tanaka A, Hirata M. Possibility of lung cancer risk in indium-exposed workers: an 11-year multicenter cohort study. J Occup Health. 2019;61(3):251-256. doi: 10.1002/1348-9585.12050. PMID: 30895696
  4. Eitaki Y, Nakano M, Kawai T, Omae K, Takebayashi T. Biological monitoring of o-toluidine in urine pretreated by an enzymatic deconjugation method. J Occup Health.2019;61(5):349-357. doi: 10.1002/1348-9585.12058.   PMID: 31002462; PMCID: PMC6718832.
  5. Nakano M, Omae K, Takebayashi T, Tanaka S, Koda S. Epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine. J Occup Health. 2018;60:307-311.   PMID: 29743389; PMCID: PMC6078838.

【生物統計・臨床研究支援分野 / Biostatistics and Clinical Research】

  1. Nagashima K, Noma H, Sato Y, Gosho M. Sample size calculations for single-arm survival studies using transformations of the Kaplan-Meier estimator. Pharm Stat. 2020. doi: 10.1002/pst.2090. Online ahead of print.
  2. Sato Y, Yamamoto M, Serizawa T, Yamada KI, Higuchi Y, Kasuya H. A graded prognostic model for patients surviving 3 years or more (GPM≥3Ys) after stereotactic radiosurgery for brain metastasis. Radiother Oncol. 2020: S0167-8140(20)31194-4.
  3. Rusthoven CG, Yamamoto M, Bernhardt D, Smith DE, Gao D, Serizawa T, Yomo S, Aiyama H, Higuchi Y, Shuto T, Akabane A, Sato Y, Niranjan A, Faramand AM, Lunsford LD, McInerney J, Tuanquin LC, Zacharia BE, Chiang V, Singh C, Yu JB, Braunstein S, Mathieu D, Touchette CJ, Lee CC, Yang HC, Aizer AA, Cagney DN, Chan MD, Kondziolka D, Bernstein K, Silverman JS, Grills IS, Siddiqui ZA, Yuan JC, Sheehan JP, Cordeiro D, Nosaki K, Seto T, Deibert CP, Verma V, Day S, Halasz LM, Warnick RE, Trifiletti DM, Palmer JD, Attia A, Li B, Cifarelli CP, Brown PD, Vargo JA, Combs S, Kessel KA, Rieken S, Patel S, Guckenberger M, Andratschke N, Kavanagh BD, Robin TP. Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study. JAMA Oncol.
  4. Obara H, Takeuchi M, Kawakubo H, Shinoda M, Okabayashi K, Hayashi K, Sekimoto Y, Maeda Y, Kondo T, Sato Y, Kitagawa Y. Aqueous olanexidine versus aqueous povidone-iodine for surgical skin antisepsis on the incidence of surgical site infections after clean-contaminated surgery: a multicentre, prospective, blinded-endpoint, randomised controlled trial. Lancet Infect Dis. 2020;20(11):1281-1289.
  5. Ishii M, Hirai I, Tanese K, Fusumae T, Nakamura Y, Fukuda K, Uchi H, Kabashima K, Otsuka A, Yokota K, Yamazaki N, Namikawa K, Fujimura T, Takenouchi T, Yamamoto Y, Nishiguchi M, Sato Y, Amagai M, Funakoshi T. Anti-PD-1 antibody therapy for epithelial skin malignancies: An investigator-initiated, open-label, single-arm, multicenter, phase II clinical trial (NMSC-PD1 Study). Medicine (Baltimore). 2020;99(44):e22913.

【ポピュレーションヘルス・地域保健分野 / Population Health Research and Community Health】

  1. Hirata A, Okamura T, Hirata T, Sugiyama D, Ohkubo T, Okuda N, Kita Y, Hayakawa T, Kadota A, Kondo K, Miura K, Okayama A, Ueshima H. Relationship between non-fasting triglycerides and cardiovascular disease mortality in a 20-year follow-up study of a Japanese general population: NIPPON DATA90. J Epidemiol.2021 Jan 16. doi: 10.2188/jea.JE20200399. [Epub ahead of print]  PMID: 33456020.
  2. Umemoto K, Kubo S, Nishida Y, Higashiyama A, Kawamura K, Kubota Y, Hirata T, Hirata A, Sata M, Kuwabara K, Miyazaki J, Kadota A, Iida M, Sugiyama D, Miyamatsu N, Miyamoto Y, Okamura T. Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study. J Atheroscler Thromb. 2020 Dec 9. doi: 10.5551/jat.61069. [Epub ahead of print]   PMID: 33298666.
  3. Hirata A, Kakino A, Okamura T, Usami Y, Fujita Y, Kadota A, Fujiyoshi A, Hisamatsu T, Kondo K, Segawa H, Sawamura T, Miura K, Ueshima H; SESSA Research Group. The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. Atherosclerosis. 2020; 313: 20-25.   PMID: 33011550.
  4. Hattori H, Hirata A, Kubo S, Nishida Y, Nozawa M, Kawamura K, Hirata T, Kubota Y, Sata M, Kuwabara K, Higashiyama A, Kadota A, Sugiyama D, Miyamatsu N, Miyamoto Y, Okamura T. Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents. Int J Environ Res Public Health. 2020; 17(16). pii: E5811. PMID: 32796692
  5. Imai Y, Hirata T, Saitoh S, Ninomiya T, Miyamoto Y, Ohnishi H, Murakami Y, Iso H, Tanaka S, Miura K, Tamakoshi A, Yamada M, Kiyama M, Ueshima H, Ishikawa S, Okamura T; Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group. Impact of hypertension stratified by diabetes on the lifetime risk of cardiovascular disease mortality in Japan: a pooled analysis of data from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan study. Hypertens Res. 2020; 43(12): 1437-1444.   PMID: 32620896.

【予防医学分野 / Preventive Medicine】

  1. Ishibashi Y, Harada S, Takeuchi A, Iida M, Kurihara A, Kato S, Kuwabara K, Hirata A, Shibuki T, Okamura T, Sugiyama D, Sato A, Amano K, Hirayama A, Sugimoto M, Soga T, Tomita M, Takebayashi T. Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry. Sci Rep. 2021 Apr 1;11(1):7407. doi: 10.1038/s41598-021-86600-9. PMID: 33795760; PMCID: PMC8016858.
  2. Harada S, Hirayama A, Chan Q, Kurihara A, Fukai K, Iida M, Kato S, Sugiyama D, Kuwabara K, Takeuchi A, Akiyama M, Okamura T, Ebbels TMD, Elliott P, Tomita M, Sato A, Suzuki C, Sugimoto M, Soga T, Takebayashi T. Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry. PLoS One. 2018 Jan 18;13(1):e0191230. doi: 10.1371/journal.pone.0191230. PMID: 29346414; PMCID: PMC5773198.
  3. Shibutami E, Ishii R, Harada S, Kurihara A, Kuwabara K, Kato S, Iida M, Akiyama M, Sugiyama D, Hirayama A, Sato A, Amano K, Sugimoto M, Soga T, Tomita M, Takebayashi T. Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan. PLoS One. 2021 Feb 10;16(2):e0246456. doi: 10.1371/journal.pone.0246456. PMID: 33566801; PMCID: PMC7875413.
  4. Fukushima K, Harada S, Takeuchi A, Kurihara A, Iida M, Fukai K, Kuwabara K, Kato S, Matsumoto M, Hirata A, Akiyama M, Tomita M, Hirayama A, Sato A, Suzuki C, Sugimoto M, Soga T, Sugiyama D, Okamura T, Takebayashi T. Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus. J Clin Lipidol. 2019 Nov-Dec;13(6):932-939.e2. doi: 10.1016/j.jacl.2019.09.002. Epub 2019 Sep 11. PMID: 31601483.
  5. Iida M, Harada S, Takebayashi T. Application of Metabolomics to Epidemiological Studies of Atherosclerosis and Cardiovascular Disease. J Atheroscler Thromb. 2019 Sep 1;26(9):747-757. doi: 10.5551/jat.RV17036. Epub 2019 Aug 2. PMID: 31378756; PMCID: PMC6753246.

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