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Tsuruoka Metabolomic Cohort study (TMCS)

The Tsuruoka Metabolomics Cohort Study (TMCS) is a large-scale population-based cohort study conducted in the city of Tsuruoka in Yamagata Prefecture, Japan. A total of 11,002 men and women aged 35–74 years participated in the baseline study between 2012 and 2015, and follow-up surveys are ongoing. The primary objective of this study is to enhance precision preventive medicine for multi-factorial, complex diseases, including non-communicable and aging-associated diseases, by improving risk stratification and prediction measures. To this end, TMCS has conducted genomic and metabolomic analyses of all participants, establishing a multi-omics database. Its robust epidemiologic study designs, high participation rate (89%), and long-term repeated surveys with complete follow-up on incidence and mortality are also strengths of this study. Together with comprehensive surveys on health, lifestyle, and social factors, we aim to advance personalized preventive medicine by utilizing molecular profiling to identify biomarkers related to the pathophysiology of disease. We collaborate with other genomic cohorts in the country and metabolomics cohorts around the world to provide insights from Japan and East Asia.

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Research finding

Charged Metabolite Biomarkers of Food Intake Assessed via Plasma Metabolomics in a Population-Based Observational Study in Japan

[PubMED]　[doi]　*

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

[PubMED]　[doi]　*

Metabolomic Profiling Reveals Novel Biomarkers of Alcohol Intake and Alcohol-Induced Liver Injury in Community-Dwelling Men

[PubMED]　[doi]　*

Metabolic Profiling of Charged Metabolites in Association with Menopausal Status in Japanese Community-Dwelling Midlife Women: Tsuruoka Metabolomic Cohort Study

[PubMED]　[doi]　*

Profiling of Plasma Metabolites in Postmenopausal Women with Metabolic Syndrome

[PubMED]　[doi]　*

Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus

[PubMED]　[doi]　*

Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison with Health Insurance Claims

[PubMED]　[doi]　*

The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults

[PubMED]　[doi]　*

The infographics with asterisks were designed by MEDICAL FIG.