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The Tsuruoka Metabolomics Cohort Study (TMCS) is a large-scale population-based cohort study conducted in the city of Tsuruoka in Yamagata Prefecture, Japan. A total of 11,002 men and women aged 35–74 years participated in the baseline study between 2012 and 2015, and follow-up surveys are ongoing. The primary objective of this study is to enhance precision preventive medicine for multi-factorial, complex diseases, including non-communicable and aging-associated diseases, by improving risk stratification and prediction measures. To this end, TMCS has conducted genomic and metabolomic analyses of all participants, establishing a multi-omics database. Its robust epidemiologic study designs, high participation rate (89%), and long-term repeated surveys with complete follow-up on incidence and mortality are also strengths of this study. Together with comprehensive surveys on health, lifestyle, and social factors, we aim to advance personalized preventive medicine by utilizing molecular profiling to identify biomarkers related to the pathophysiology of disease. We collaborate with other genomic cohorts in the country and metabolomics cohorts around the world to provide insights from Japan and East Asia.
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